Planar Cell Polarity Signaling in Mammalian Cardiac Morphogenesis
نویسندگان
چکیده
منابع مشابه
Coupling planar cell polarity signaling to morphogenesis.
Epithelial cells and other groups of cells acquire a polarity orthogonal to their apical-basal axes, referred to as Planar Cell Polarity (PCP). The process by which these cells become polarized requires a signaling pathway using Frizzled as a receptor. Responding cells sense cues from their environment that provide directional information, and they translate this information into cellular asymm...
متن کاملPlanar Cell Polarity Signaling in Collective Cell Movements During Morphogenesis and Disease
Collective and directed cell movements are crucial for diverse developmental processes in the animal kingdom, but they are also involved in wound repair and disease. During these processes groups of cells are oriented within the tissue plane, which is referred to as planar cell polarity (PCP). This requires a tight regulation that is in part conducted by the PCP pathway. Although this pathway w...
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Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial polarization requires the intervention of several fundamental cell processes, whose integration in space and time is only starting to be elucidated. To understand what governs the building of epithelial tissues during development, it is essential to consider the polarization process in the context o...
متن کاملCell packing influences planar cell polarity signaling.
Some epithelial cells display asymmetry along an axis orthogonal to the apical-basal axis, referred to as planar cell polarity (PCP). A Frizzled-mediated feedback loop coordinates PCP between neighboring cells, and the cadherin Fat transduces a global directional cue that orients PCP with respect to the tissue axes. The feedback loop can propagate polarity across clones of cells that lack the g...
متن کاملPlanar Polarity and Tissue Morphogenesis
Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors. These two systems involve different sets of proteins but both use dir...
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ژورنال
عنوان ژورنال: Pediatric Cardiology
سال: 2018
ISSN: 0172-0643,1432-1971
DOI: 10.1007/s00246-018-1860-5